Granisetron in Dog Plasma Assay

 

 

 

 

 

Method: LC-MS/MS

Matrix: Dog Plasma

Anticoagulant: Potassium EDTA

Storage Temperature: -20 °C and -70 °C

LLOQ: 0.1 ng/mL

ULOQ: 51.2 ng/mL

Sample Volume: 100 mcL

Precision & Accuracy:

  • LLOQ QC: 6.4% CV; -3.8% Bias
  • Low QC: 3.4% CV; -4.0% Bias
  • Mid QC: 1.9% CV; 0.0% Bias
  • High QC: 3.0% CV; -1.1% Bias
  • Above Range QC (5x Dilution): 1.7% CV; -6.1% Bias

Stability:

  • Short-Term (Bench-Top): 28.5 hours
  • Long-Term: 41 days at -20 °C
  • Freeze/Thaw Cycles: 4

Method Number: V2342P1