Aprepitant Compound - PNG

 

 

 

 

 

Method: LC-MS/MS

Matrix: Human Plasma

Anticoagulant: K2EDTA

Storage Temperature: -20 °C and -70 °C

LLOQ: 10 ng/mL

ULOQ: 5120 ng/mL

Sample Volume: 50 mcL

Precision and Accuracy:

  • LLOQ QC: 7.2% CV; 5.0% Bias
  • Low QC: 3.1% CV; 3.3 % Bias
  • Mid QC: 3.4% CV; 3.4% Bias
  • High QC: 2.7% CV; 0.3% Bias
  • Above Range QC (5x Dilution): 1.4% CV; -7.5% Bias

Stability:

  • Short-Term (Bench-Top): 6.5 hours
  • Long-Term: 75 days at -20 and -70 °C
  • Freeze/Thaw Cycles: 4 (-20 °C /RT and -70 °C /RT)
  • Whole Blood: 1 hour

Method Number: V2429P1