Atorvastatin Compound

 

Method: LC-MS/MS

Matrix: Human Plasma

Anticoagulant: K2EDTA

Storage Temperature: -20 °C and -70 °C

LLOQ: 0.2 ng/mL

ULOQ: 102 ng/mL

Sample Volume: 300 mcL

Precision & Accuracy:

  • LLOQ QC: 7.5% CV; -1.6% Bias
  • Low QC: 3.5% CV; -4.4% Bias
  • Mid QC: 2.1% CV; -2.0% Bias
  • High QC: 2.3% CV; 1.2% Bias
  • Above Range QC (5x Dilution): 4.1% CV; -2.1% Bias

Stability:

  • Short-Term (Bench-Top): 4 hours (Ice Bath)
  • Long-Term: 41 days at -20 °C and -70 °C
  • Freeze/Thaw Cycles: 4

Comments: Validated for the quantitation of Atorvastatin and its 4-Hydroxy Metabolite and in Presence of Losartan and its Metabolites

Method Number: V2397P1